Posted by Larry Hoover on November 26, 2004, at 10:25:56
In reply to Re: Sleep, selegiline and autoreceptors » Larry Hoover, posted by Ktemene on November 25, 2004, at 23:22:54
> Hi Larry,
>
> I was sorry to read that you were having a problem with acid reflux and Selegiline. Are you still having that problem?I seem to be able to avoid it, mostly, by dissolving the selegiline under my tongue. It's a really sensitive system; the effective selegiline dose and the reflux-inducing dose are not very far apart.
I really want to get some liquid selegiline, but it is not available in Canada. I'm going to see if I can get my doctor to go to the bother of importing it under Special Access guidelines.
> For almost 5 months now I have been taking 5 mg Selegiline HCI powder from a capsule and holding it under my tongue to try to get some sublingual absorption, just as you do. And I also use DLPA (or L-PA) on an empty stomach as you do, and it does seem to increase the good effects of Selegiline. (I also exercise after taking the DLPA while still on an empty stomach, and then take the Selegiline after breakfast.) Selegiline is the most effective medication for my fatigue-ridden atypical depression that I have tried (and I have tried a lot of medications). The biggest problem I have is insomnia, and I noticed that you have it also. You said a while back that your sleep cocktail was 25 mg trimipramine, about .4 mg melatonin, 30 mg temazepam, and about 1.5 grams taurine. I wondered if you had thought about raising the dosage of melatonin? I know that you have reservations about melatonin. But I wondered what you thought about some of the literature that suggests that melatonin and Selegiline work synergistically together? This is one I came across on PubMed: Synergistic effects of melatonin and deprenyl against MPTP-induced mitochondrial damage and DA depletion.Neurobiol Aging. 2003 May-Jun;24(3):491-500.
> PMID: 12600724Thanks for the reference. I might as well try increasing my dose of melatonin. My insomnia is on the verge of making me dysfunctional altogether.
> I think I also read somewhere that melatonin stimulates brain glutathione peroxidase activity. Several posters have mentioned that if you are taking Selegiline then you are raising SOD activity, but that to keep antioxidant systems in balance you should take NAC or some other antioxidant for that effect. But could melatonin do just as well?I think you're onto something here. The combination protects against dopamine auto-oxidation, which was one of Ray's concerns.
Your link has that bit: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12600724
This one shows the glutathione effect:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15521903If you take the microgram/kg ratio and apply it to humans, you're in the ballpark of 4-8 mg/day.
> I also found an article that said that chronic melatonin treatment counteracts glucocorticoid-induced dysregulation of the HPA axis in the rat. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9630434&dopt=Citation) My HPA axis was fried when I was a child, and if any medication change that I would love it.Mine too. OK, you've got good grounds for a melatonin trial. Thanks.
> By the way, I have really enjoyed reading your posts ever since I discovered Psycho-Babble back in 2002.
>
> KtemeneThank you. And thanks for joining in.
Lar
poster:Larry Hoover
thread:387192
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/420478.html