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Re: More on Tryptophan- does illness affect efficacy?

Posted by yahtzee on November 22, 2004, at 15:18:26

In reply to More on Tryptophan- does illness affect efficacy?, posted by jasmineneroli on November 18, 2004, at 20:17:46

> Hey guys!
> Felt really crappy over the weekend and blamed it on the lower Tryptophan dose (1000mg). It turns out I had the 'flu!!!
> Well, in my own defense, it wasn't an impulsive conclusion to draw, because so MANY of my bad drug S/E's, felt like awful body flu's and 3 weeks later I realized that flu doesn't last that long. So I drop the drug, and yay, feel better immediately!!
> However, my sleep had not improved further, after the initial imrovement (from 3-4 nightly awakenings to 2). So last night I increased the bedtime Trypt. to 2000mg (from 1500mg). I slept for 5 straight hours before waking up this time, fell asleep easily and woke to my alarm. That's a huge improvement!
> I'm going to stay at 2000mg for now, but will likely increase it further. I want to sleep THROUGH the night, and have an even mood. Not too much to ask, is it?
> I had quite a bit of irritable anxiety during the flu/1000mg-1250mg Trypt period. Would an illness have an affect on my utilization of Trypt. making it not as effective? If that's the case, should supplements be increased when the immune system is under attack?
> Or do I still need more Trypt. for better anxiolytic effects?
> Thanks,
> Jas
> PS
> Does anyone know which P450 enzymes inhibit/enhance Tryptophan???
>

I've been trying tryptophan for the past 2.5months, and have noticed that everytime I have a cold (which is surprisingly often with a baby at nursery!), my mood is v.negative especially in the first 3 or 4 days of the colds' onset. Once it's over the tryptophan "kicks" in and things are more balanced in terms of mood. Also noticed that the cold tends to linger longer whilst taking tryptophan.

Just an observation.

Rgds,

Y


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