Psycho-Babble Alternative | about alternative treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: More on Tryptophan- does illness affect efficacy? » jasmineneroli

Posted by raybakes on November 20, 2004, at 13:28:14

In reply to Re: More on Tryptophan- does illness affect efficacy?, posted by jasmineneroli on November 19, 2004, at 17:10:25


>
> *Thanks Ray, that makes HUGE sense, considering how I was feeling.
> I don't know whether or not to increase the dosage if I become ill again at some point, to try to maintain a stable level. What do you think?
> Jas

I'm not sure what would be best, but this is what one abstract said..

'Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism.'

".....and the enzyme (IDO) is induced in rodents after administration of interferon inducers, or influenza virus"


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1907934

Just wonder if it might be like trying to fill a bucket with holes in it, during a flu infection. Autoimmune people tend to overproduce interferon gamma, and so may break down too much tryptophan - niacinamide can help stop this pathway, as can glutathione, methyl donors and other antioxidants. But also bear in mind that tryptophan may prolong a viral illness...

"since the presence of excess amounts of l-tryptophan abrogates the antiviral effect induced by IFN-gamma and the combination of IFN-gamma and TNF-alpha."

'Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indoleamine 2,3-dioxygenase.'

Institut fur Virologie, Heinrich-Heine-Universitat, Universitatsstrasse 1, D-40225 Dusseldorf, Germany.

Genital herpes simplex virus type 2 (HSV-2) is a significant clinical problem. Infection in pregnancy may result in disseminated infection of the newborn with encephalitis. We analyzed the antiviral effects induced by interferon-gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in cervix carcinoma cells (HeLa) and astrocytoma cells (86HG39). We found that replication of HSV-2 in HeLa cells and in 86HG39 cells is inhibited after stimulation of the cells by IFN-gamma and TNF-alpha. The antiviral effect of IFN-gamma is enhanced in the presence of TNF-alpha, while stimulation by TNF-alpha alone did not induce antiviral activity. We found that IFN-gamma induces a strong activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and in addition, that the IFN-gamma-induced IDO activity was enhanced in the presence of TNF-alpha. Furthermore, we found that the induction of IDO activity is responsible for the inhibition of herpes simplex virus replication, since the presence of excess amounts of l-tryptophan abrogates the antiviral effect induced by IFN-gamma and the combination of IFN-gamma and TNF-alpha. We therefore conclude that the antiviral effect against HSV-2 mediated by type II interferon and TNF-alpha are dependent on IDO activation

Hope it's not too confusing!

Ray


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Alternative | Framed

poster:raybakes thread:417678
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/418285.html