Posted by raybakes on November 19, 2004, at 16:00:25
In reply to More on Tryptophan- does illness affect efficacy?, posted by jasmineneroli on November 18, 2004, at 20:17:46
> Hey guys!
> Felt really crappy over the weekend and blamed it on the lower Tryptophan dose (1000mg). It turns out I had the 'flu!!!
> Well, in my own defense, it wasn't an impulsive conclusion to draw, because so MANY of my bad drug S/E's, felt like awful body flu's and 3 weeks later I realized that flu doesn't last that long. So I drop the drug, and yay, feel better immediately!!
> However, my sleep had not improved further, after the initial imrovement (from 3-4 nightly awakenings to 2). So last night I increased the bedtime Trypt. to 2000mg (from 1500mg). I slept for 5 straight hours before waking up this time, fell asleep easily and woke to my alarm. That's a huge improvement!
> I'm going to stay at 2000mg for now, but will likely increase it further. I want to sleep THROUGH the night, and have an even mood. Not too much to ask, is it?
> I had quite a bit of irritable anxiety during the flu/1000mg-1250mg Trypt period. Would an illness have an affect on my utilization of Trypt. making it not as effective? If that's the case, should supplements be increased when the immune system is under attack?
> Or do I still need more Trypt. for better anxiolytic effects?
> Thanks,
> Jas
> PS
> Does anyone know which P450 enzymes inhibit/enhance Tryptophan???
>Don't know what p450 enzymes affect tryptophan hydroxylase, but St John's Wort has a profound effect on P450s.
During infection or inflammation peroxynitrite inhibits tryptophan hydroxylase. Also the enzyme IDO is upregulated to break down tryptophan via the kynurenine pathway as tryptophan degradation seems to be essential to help in fighting infection. Inflammation in autistic of chronic fatigue also breaks tryptophan down into a chemical called IAG, thought to disrupt serotonin.
Ray
poster:raybakes
thread:417678
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/417984.html