Posted by KaraS on November 11, 2004, at 15:16:38
In reply to Re: dopamine autoreceptor problem, posted by linkadge on November 11, 2004, at 14:45:18
> Amisulpride is a dopamine autoreceptor antagonist. However, it also blocks some of the postsynaptic receptors. This kind of cancells out the effect. You get more dopamine but some of its targets are blocked. This is why it is more of a antipsychotic than antidepressant.
I didn't realize that. Does that also pertain to low dose (under 200 mgs.) of Amisulpride when it's used for depression?
> I would assume that increasing dopamine could desensitize the autoreceptor in the same way that SSRI's eventually desensitize the serotonin autoreceptor.In that article by Dr. Goldstein he stated that it "pained" him to say it but there is no medication for this problem (other than that drug that seems to have died in development). Fortunately, Todd (King Vultan) mentioned that theoretically you ought to be able to downregulate these DA receptors in the same way that we do with SE receptors. Then I read a couple of abstracts that backed-up the theory.
> I would assume that selegeline would have a similar effect to parnate in this regard.
>
> Right now I am just taking lithium, and epival, and coffee. Coffee really helps calm me down.
> With regards to improving anhedonia, I exercise a LOT, and combine this with chocolate.
I thought you were taking an SSRI for some reason(?) I worry about taking those unopposed with dopamine. I wonder if long-term SSRI use could have created this DA autoreceptor hypersensitivity in my case. Do you have any thoughts on this?Strange to read about someone drinking coffee to calm down... but I guess it's no stranger than me using Ritalin as a sleeping pill.
> Exercise itself can drastically raise levels of PEA in the brain. I am hoping that combining this with chocolate can deal a double whammy.I've definitely got to do more of it...
> I live in canada, and not too many doctors have started experimenting with selegeline for depression.
There aren't that many in the U.S. that are open to it either. I think it's easier to try it on your own here.
> Linkadge
(comments interspersed above also)Thanks!!!!!! You have told me everything it has taken me months to figure out, clarified some things plus told me some other things that I hadn't figured out yet. I really appreciate it. You sound so sharp and clear these days. I can tell you are doing much better and I'm so glad.
Kara
poster:KaraS
thread:413185
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/414636.html