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Re: dopamine autoreceptor problem » linkadge

Posted by KaraS on November 11, 2004, at 13:46:47

In reply to dopamine autoreceptor problem, posted by linkadge on November 11, 2004, at 10:46:25

>>> Wow, I react the same way to stimulants, coffee, ritalin etc.

>>> There would be two ways in theory to correct the problem. One being somehow downregulating the autoreceptors, and the second by taking a dopamine autoreceptor antagonist (unfortunately none are available at the time being)

>>> If it was serotonin autoreceptor problem, you could take pindolol or lithium both potent serotonin autoreceptor antagonists.

Hi linkadge,

Ironically, coffee is the only one of the stimulants/dopaminergics I've tried so far that I don't react paradoxically to (fortunately).

Yes, I recently read an abstract that said Parnate was able to downregulate DA autoreceptors in mice. I'm looking further into selegiline + DLPA also. Any other suggestions for meds that might do this?

Aren't Sulpiride and Amisulpride DA antagonists?
I had been trying to get more information about OSU6162 which is a drug in development but wasn't able to find out very much. I posted to the main board about it but got no response (at a time when JrBecker was posting so I doubt there's much going on with that medication right now).

Dr. Goldstein suggests that desensitization can also occur by ""uncoupling," a loss of receptor signaling function." How that translates into treatment I don't know yet. (Do you?)

Are you completely lacking in motivation as I am? Are you anhedonic? I have bouts of this but overall haven't had complete anhedonia.
What are you doing/taking, if anything, to address this condition?

Kara


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poster:KaraS thread:413185
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/414602.html