Posted by raybakes on October 17, 2004, at 12:57:24
Came across some more info about the oxidation of dopamine/catecholamines. The degradation to toxic quinones like dopachrome and adrenochrome by monoamine oxidase seems a problem in mental illness. Increasing the activity of the methyltransferase enzyme COMT, and maybe sulphation and glucuronidation, might be a way to reduce the production of these toxic by-products - anyone heard anything about them before?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1956581&dopt=Abstract
the radical superoxide can oxidise catecholamines too, so wonder whether depletion of dopamine by autoxidation can then change receptor sensitivity too?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2982420&dopt=Abstract.
and another...
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8913362
the toxic quinones need to be detoxified by our friend glutathione!
Ray
poster:raybakes
thread:404137
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/404137.html