Posted by raybakes on November 12, 2004, at 14:11:16
In reply to Re: dopamine oxidation » raybakes, posted by Larry Hoover on November 11, 2004, at 10:56:35
> OK, you bum, you made me get out my textbooks.Sorry Lar :(
I see the oxidative stress as the root, and acidosis as the outcome.I can go with that!
> What is it, explicitly, that you do to improve buffering capacity? And separately, what do you do to support your mitochondria?
Carnosine (good for detoxing aldehydes from mitochondrial lipid peroxidation), carnitine and creatine all work well for both.Do better with precursors - arginine and methyl factors for creatine - lysine and methyl factors for carnitine.
CoQ10 also needs methylation, and tyrosine, biopterin and cholesterol.
Also looking at ways to reduce superoxide and peroxynitrite as they uncouple a lot of mitochondrial enzymes.
The balance of arginine/NOS/biopterin/methylation seems important. Low biopterin or low arginine can switch NOS to produce superoxide instead of nitric oxide. Arginine without methyl factors can increase homocysteine.
I'm being cautious with NAC at the moment because although I want to raise glutathione, I get the feeling that cysteine dioxygenase (interleukin 1, 6 and TNF alpha related I think) doesn't clear the excess of cysteine properly for me - my lungs burned when I last took NAC. Do badly with sulfites (triggers superoxide production from NADPH), taking molybdenum worsens my symptoms, but MSM improves them dramatically
> One thing at a time, Ray. I must pace myself.
Sorry, hope that's not too much - I think I like forests more than trees!Ray
poster:raybakes
thread:404137
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/415083.html