Posted by tealady on October 17, 2004, at 17:35:32
In reply to Re: dopamine oxidation » raybakes, posted by Larry Hoover on October 17, 2004, at 14:04:51
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1956581&dopt=Abstract
>
> "This BH4/DHPR-mediated antioxidation system is as effective as other antioxidation agents such as ascorbic acid, cysteine and reduced glutathione."
>There's that tetrahydrobiopterin (BH4) and also DHPR another opteridine. I think Ray takes biopterin? What is it ?
> I.e. keep your antioxidant supplies up (avoid oxidative stress). Make sure you take vitamin C, and selenium.
>
> > the radical superoxide can oxidise catecholamines too, so wonder whether depletion of dopamine by autoxidation can then change receptor sensitivity too?
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> > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2982420&dopt=Abstract.
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> "Adrenaline oxidation was unaffected by the presence of exogenous linolenic acid or methylarachidonic acid, while arachidonic acid, with a Km for this reaction of 175 microM, showed a marked stimulatory effect. This activation was suppressed by superoxide dismutase, catalase and NaCN, while mannitol was without effect."
>
> I.e. shift the omega-6:omega-3 balance to reduce arichidonate release by phospholipase A2, and ensure adequate zinc and manganese to maintain SOD function.
>
> > and another...
> >http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8913362
>
> "N-acetylcysteine produced a dose-dependent decrease in dopamine-induced cell death; this correlated with a decrease in peroxide formation."
>
> NAC spares glutathione, so again, you have antioxidant defenses implicated, rather than the dopamine, IMHO.
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> > the toxic quinones need to be detoxified by our friend glutathione!
> >
> > Ray
>
> Actually, glutathione et al keep them from forming in the first place.
>What do you think of these comments abou not taking NAC if you have amalgam fillings?
Some nutritional authorities recommend taking a form of cysteine known as N-acetyl-cysteine (NAC), but I would advise against using this supplement if you still have mercury amalgam fillings because it could interfere with the detoxification of the mercury. Personally I consume 300 mg of alpha lipoic acid and 5,000 mg of glutamine and 2,500 mg of vitamin C before I do my seven-mile run as I believe it will maximize the glutathione production to decrease the damage from the free radicals that I generate when I exercise. Controlling the damage from free radicals is one of the keys to slowing down the aging process.
http://www.mercola.com/2000/jun/24/sugar_glutathione.htm
>
> Oxidative stress plays havoc with your sulphur metabolism. So, cysteine, carnitine, taurine, glutathione, SAMe....many key molecules get trashed because sulphur gets trashed before carbon. The reason many antixidants have sulphur atoms is sacrificial. Selenium substitutes for sulphur to become even more sacrificial (as in seleno-cysteine). If there isn't enough sulphur to martyr itself on our behalf, other stuff gets mucked right up, or sulphur-bearing molecules we need for other purposes get destroyed instead.
>
What is the best way of geeting sulphur? Betaine? what form of betaine? TMG I think you used too take?? I'm putting an order in soon from O'd
seas.
Also
http://www.dr-bob.org/babble/alter/20040928/msgs/403607.html
end of post on my sulphur sensitivies..
I'm confused what this means I should do if I want to get my sulphur intake up.
I am trialing adding a little Epsom salts (like a small pinch) to a bottle of water at present.Maybe one day I'll understand a bit better <g>.
I'm doing one subject in Cell Biology this semester..next year 1st year Chem <g>.Jan
poster:tealady
thread:404137
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/404204.html