Posted by Roslynn on April 11, 2023, at 14:50:02
In reply to Re: To SLS » SLS, posted by undopaminergic on April 11, 2023, at 10:34:33
> >
> > Theoretically, taking two drugs that increase serotonin neurotransmission - even if they have different mechanisms - have the potential to cause Serotonin Syndrome.
> >
>
> Not "even", but "especially", because of the potential for synergistic effects, as in the case of MAOI+SSRI. SSRI+SSRI would be merely additive, and moreover, there is a peak of 100% reuptake inhibition which is insufficient to cause life-threatening serotonin toxicity. Venlafaxine (Effexor), however, seems to be more potent in elevating serotonin according to Gillman; he speculates that it may have serotonin-releasing properties.
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> > > Or can you taper Effexor while starting up Serzone?
> >
> > I doubt doing that would reduce any risks.
>
> Tapering would allow you time to notice early signs of serotonin toxicity, so that you can stop tapering, and if necessary, reduce the dose.
>
> -undopaminergic
>Thank you for the information.I though Effexor+Serzone was one of Stahl's heroic combos?
"If I could survive one more day or one more hour, I might find a way to get back home."
-Elizabeth Smart
poster:Roslynn
thread:1122008
URL: http://www.dr-bob.org/babble/20230117/msgs/1122014.html