Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re:Neuroleptics brain specific antihistaminergic?

Posted by undopaminergic on February 6, 2023, at 12:58:00

In reply to Re:Neuroleptics brain specific antihistaminergic?, posted by SLS on February 6, 2023, at 8:03:02

> Hi.
>
> In re: The Blood-Brain Barrier and anticholinergic drugs.
>
> Anticholinergic drugs enter the brain at different rates.
>
> Trospium (Sanctura) is an anticholinergic (muscarinic) drug used to treat overactive bladder, a peripheral function. However, it seems to be blocked from entering the brain almost entirely by the BBB. It can't even be detected in the cerebrospinal fluid (CSF). Trospium effectively treats a broad array of maladies like overactive bladder. It accomplishes this by reducing the tone of the muscles involved. Anticholinergics work by blocking the (muscranic) acetylcholine receptors that normally innervate muscles to contract. These are peripheral effects. However, when an anticholinergic drug makes its way into the brain / CNS, central side-effects can occur:
>
> 1. Short-term: Produces impairments in cognition and memory, confusion, impaired concentration, restlessness, agitation, and delirium.
>
> 2. Long-term: Increases risk for developing irreversible dementia.
>
> Hopefully, the risk of contracting dementia when using trospium long-term will be much lower than for other anticholinergic drugs.
>
> https://pubmed.ncbi.nlm.nih.gov/22390261/
>
>
> - Scott

For local (such as nasal mucosa) treatment ipratropium and tiotropium are other antimuscarinics that don't cross the blood-brain-barrier. I'm using the former to reduce night-time salivation.

-undopaminergic


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:undopaminergic thread:1121718
URL: http://www.dr-bob.org/babble/20230117/msgs/1121742.html