Posted by SLS on February 5, 2023, at 19:43:04
In reply to Re:Neuroleptics brain specific antihistaminergic?, posted by Lamdage22 on February 5, 2023, at 14:14:31
> Next question: Do MAOI increase histamine?
Like dopamine (DA), norepinephrine (NE), and serotonin (5-HT), the histamine molecule is a biogenic amine. Monoamine oxides type A (MAO-A) leaves histamine virtually untouched. MAO-B metabolizes (breaks-down) histamine, but to a very small degree. MAO exists *inside* the neuron, but not outside the neuron. Histamine is metabolized *outside* the neuron by an enzyme called diamine oxidase (DAO). Another enzyme located outside the neuron is catechol-O-methyltransferase (COMT). As with the MAO enzyme located inside the neuron, it metabolizes DA, NE, and 5-HT outside the neuron, but to a much smaller degree.I don't know very much about how histamine functions in the body.
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poster:SLS
thread:1121718
URL: http://www.dr-bob.org/babble/20230117/msgs/1121737.html