Posted by linkadge on September 30, 2022, at 15:46:14
In reply to Re: Clorgyline is a MAOI specific for MAO-A. » SLS, posted by undopaminergic on September 30, 2022, at 6:28:50
In addition to its effects on MAO, Clorgyline is a potent agonist at the imidazoline receptors. Imidazoline receptors are only partially characterized, but agonists at this receptor system appear to have significant antidepressant effects. Imidazoline receptors modulate the alpha-2 receptors and may also have an ability to regulate MAO levels (independent of the direct effects of clorgyline). Rapid acting antidepressants (like agmatine) are imidazoline agonists. It is entirely possible that this effects contributes to the antidepressant effects of clorgyline (and separates it from other MAOIs).
Linakdge
poster:linkadge
thread:1120765
URL: http://www.dr-bob.org/babble/20220917/msgs/1120825.html