Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Oral deprenyl vs bupropion?

Posted by SLS on June 7, 2022, at 7:28:09

In reply to Re: Oral deprenyl vs bupropion?, posted by linkadge on June 6, 2022, at 18:39:45

Hi.

L-Deprenyl / selegeline / EMSAM is *selective* for MAO-B, but only at low dosages. At higher dosages, selegeline becomes non-selective and MAO-A is also inhibited, Of these two types of MAO enzymes, MAO-A is the the one that is associated with antidepressant effects. The package label for EMSAM is explicit regarding this. Clorgyline is no longer available, but it is an irreversible *specific* inhibitor of MAO-A. It doesn't inhibit MAO-B at all. The NIH had considered it the most powerful antidepressant in the world, but reserved it for their most treatment-resistant cases of treatment-resistant depression - TRD. It left me improved, but they would not allow me to combine it with a tricyclic antidepressant (TCA) like desipramine or nortriptyline, which I had needed to add to Nardil or Parnets in order to respond. Ultimately, they had to discontinue giving clorgyline to their patients because adverse cardiac events were reported.

Moclobemide is another MAOI that is specific for MAO-A. It is a reversible inhibitor of monoamine oxidase (RIMA). Unfortunately, it is reversible rather than irreversible, leaving it an inferior choice. Some people get amazing results in the first week at 300 mg/day. However, dosage escalation is usually inevitable to retain the antidepressant response. The maximum dosage is usually considered to be 1200 mg/day. Still, very few people remain improved indefinitely on moclobemide.

In summary, inhibiting MAO-A is sufficient to yield an improvement in depression.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1119824
URL: http://www.dr-bob.org/babble/20220530/msgs/1119850.html