Posted by SLS on September 10, 2010, at 15:39:28
In reply to Re: nortripytline + MAOi? anti histamine interraction » SLS, posted by linkadge on September 10, 2010, at 10:21:56
> I don't really know of any evidence that nardil and parnate are substantially different in their MAO effect. Both drugs inhibit both MAOA/B roughly equally.
>
> The difference may be due to secondary activities of the two agents. Nardil inhibits GABA metabolism leading to higher levels of GABA. This could counteract some of the stimulatory nature of the drug.
>
> Perhaps nardil is more potent an MAOI i.e. more inhibition at lower doses?Darn. I read a nice article about it just the other day. I doubt I can find it again.
Anyway, for what it's worth - from Wiki:
http://en.wikipedia.org/wiki/Tranylcypromine
"Tranylcypromine acts as a nonselective and irreversible inhibitor of monoamine oxidase.[1][2] Regarding the isoforms of monoamine oxidase, it shows slight preference for the MAOB isoenzyme over MAOA."
- ScottThe measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:961847
URL: http://www.dr-bob.org/babble/20100908/msgs/961969.html