Posted by linkadge on September 10, 2010, at 10:18:00
In reply to Re: nortripytline + MAOi? anti histamine interraction » linkadge, posted by Conundrum on September 10, 2010, at 7:50:00
The problem occurs when your combine potent serotonin reuptake inhibition with MAO-A inhibition. As a result, the body cannot properly metabolize serotonin leading to excessive levels. This results in serotonin syndrome (a potentially life threateneing condition).
Since nortriptyline is much more potent a NRI, it has generally been used safely with MAOIs
Linkadge
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thread:961847
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