Posted by desolationrower on January 10, 2009, at 1:34:23
In reply to Re: Antibiotic (doxycycline) treatment for depression, posted by SLS on January 9, 2009, at 21:55:53
> > yes exactly there are many ways to decrease inflammation.
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> I'm sure there are.
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> The thing with doxycycline is that it seems to work in clinical settings. Unfortunately, the many other substances mentioned along this thread have not been tested to the best of my knowledge.
>
> Brain inflammation as a characteristic of Alzheimers Dementia:
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> http://www.ncbi.nlm.nih.gov/pubmed/18673008?ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
>
> Doxycycline is effective in reducing inflammation by inhibiting matrix metalloproteinases:
>
> http://www.ncbi.nlm.nih.gov/pubmed/19088876?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
>
> A trial of doxycycline in Alzheimers Disease:
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> http://www.ncbi.nlm.nih.gov/pubmed/14962152?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
>
> Taken together, these abstracts suggest that doxycycline reduces brain inflammation via a mechanism unrelated to its antibiotic effects, and that this drug is effective in treating Alzheimers Disease behavioral and mood aberations, presumably by reducing brain inflammation.
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> I am sure that not all anti-inflammatories are built alike. I would be cautious in wanting to declare all anti-inflammatory substances of equal value in treating the various neuropsychiatric illnesses.
>
>
> - ScottYes, there is a multitude of inflammatory cytokines, but this thread is hardly littered with links to studies showing this particular drug is an effective antidepressant. I can't tell if you are arguing that it would be one, because it is antinflammatory, or that the reason it is effective is the antiinflamatory action. Either way i don't see much evidence.
-d/r
poster:desolationrower
thread:872561
URL: http://www.dr-bob.org/babble/20090104/msgs/873100.html