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Re: Antibiotic (doxycycline) treatment for depression

Posted by SLS on January 9, 2009, at 21:55:53

In reply to Re: Antibiotic (doxycycline) treatment for depression, posted by desolationrower on January 9, 2009, at 20:50:22

> yes exactly there are many ways to decrease inflammation.

I'm sure there are.

The thing with doxycycline is that it seems to work in clinical settings. Unfortunately, the many other substances mentioned along this thread have not been tested to the best of my knowledge.

Brain inflammation as a characteristic of Alzheimers Dementia:

http://www.ncbi.nlm.nih.gov/pubmed/18673008?ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


Doxycycline is effective in reducing inflammation by inhibiting matrix metalloproteinases:

http://www.ncbi.nlm.nih.gov/pubmed/19088876?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


A trial of doxycycline in Alzheimers Disease:

http://www.ncbi.nlm.nih.gov/pubmed/14962152?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


Taken together, these abstracts suggest that doxycycline reduces brain inflammation via a mechanism unrelated to its antibiotic effects, and that this drug is effective in treating Alzheimers Disease behavioral and mood aberations, presumably by reducing brain inflammation.

I am sure that not all anti-inflammatories are built alike. I would be cautious in wanting to declare all anti-inflammatory substances of equal value in treating the various neuropsychiatric illnesses.


- Scott

 

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poster:SLS thread:872561
URL: http://www.dr-bob.org/babble/20090104/msgs/873069.html