Posted by sunkistcat79 on January 8, 2009, at 17:10:51
In reply to Re: BUPRENORPHINE, posted by Sigismund on January 8, 2009, at 14:06:51
> How did it stop working? Suddenly? Slowly?
Are we talking about opiate tolerance here?
>
> With other opiates it felt (to me) as if tolerance was total when blood levels of the opiate were even.The buprenorphine stopped working slowly.
From my own personal research, as far as tolerance, the whole point of bupe. is that you don't need more and more and more to get the same effect (you may have to increase your dose to find your working dose, but once you get there, you can stay on it indefinitely - they call it the Ceiling Effect). This is one of the reasons why it's market is for people who are dependent on opioids.After doing some more research, my current hyppothesis is that my endorphins are so absurdely low (every aspect of my life points to this as well) that I just need a very large amount of bupe. It worked at first but then I needed more and never got up to my proper dose (different than the general meaning of "increased tolerance".)
Think about this. The first time I ever took an opioid, I took it for about 2 weeks and, like everyone else, I always needed to increase my dose, but this experience never changed: 30 minutes after taking my dose (prescribed for pain), I felt sleepy/high-ish. This wore off in about 45 mins. and left me clearer, happier, calmer, and leveler than I HAVE ANY RECOLLECTION OF.
Doesn't it make sense that upon taking the opioid, there was a relatively high amount of the chemical in my system (a system that had been very devoid of endorphins) and it went into overload (hence- feeling high). Most people feel high for hours, but this wore off for me because soon, the chemical leveled out and instead of having an above-average amount in my system, now I just have an average amount.
I hope that made sense. I'm feel I'm having a hard time articulating myself well.
Thanks for your post....
What do you think of what I just wrote?
poster:sunkistcat79
thread:872613
URL: http://www.dr-bob.org/babble/20090104/msgs/872808.html