Posted by cache-monkey on April 12, 2007, at 20:33:01
In reply to sri, dopamine, posted by med_empowered on April 9, 2007, at 23:52:53
Thanks for the thoughts, med_empowered. I really think that something changed in my brain after being on Celexa/Wellbutrin. I've never been able to get the agitation to calm down since going off. My functional dx is BP NOS, but outside of a brief respite on Tegretol (before my body went allergic), I haven't gotten much relief from the mood stabilizers.
I guess I'd like to try an SSRI again, but I worry that it will make things indelibly worse...
Anyway, thanks again.
> well, sris sometimes cause TD. Apparently its been observed in long-term prozac and I think some effexor patients. Also, just as some researchers think patients "need" neuroleptics long-term only b/c of D2 supersensitivity secondary to long-term neuroleptic use, so too it appears that some patients "need" antidepressants long-term b/c of brain changes caused by long-term, high-dose antidepressant use. I personally think the dopamine effect with sris is probably also a big part of their effects--the mild stimulant/agitation from pumped up serotonin, the dulling from reduced dopamine, plus the additional effects of either mild sedation or mild stimulation from secondary effects on other neurotransmitters...SRIs seem to me to be kind of like low-dose neuroleptics PLUS (other milder effects). Just my thoughts.
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poster:cache-monkey
thread:747867
URL: http://www.dr-bob.org/babble/20070407/msgs/749393.html