Re: RLS, Akathisia + Dopamine D-2 receptors?

Posted by hgi698 on April 9, 2007, at 17:51:35

In reply to RLS, Akathisia + Dopamine D-2 receptors?, posted by cache-monkey on April 9, 2007, at 15:13:14

"Dopamine receptor blockade in the mesocortical dopamine tracts appears to be involved in akathisia. PET studies have shown D2 receptor occupancy in the striatum is associated with the development of akathisia." I think that ssri's can reduce the firing of dopaminergic neurons leading to a reduction in dopamine levels and signaling via the D2 receptor. This alone would cause the akathisia. After a few weeks it would be expected that your D2 receptors would upregulate to compensate for the decreased dopamine. I think this upregulation would tend to improve the akathisia because its your brain's mechanism to maintain homeostasis. Like if you took cocaine you'd feel euphoric, but your d2 receptors would downregulate after a while to keep your mood in check.

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Fellow pharm-geeks: a question about terminology cache-monkey 4/7/07
Re: Fellow pharm-geeks: a question about terminology » cache-monkey saturn 4/7/07
Re: Fellow pharm-geeks: a question about terminology » cache-monkey Larry Hoover 4/8/07
RLS, Akathisia + Dopamine D-2 receptors? cache-monkey 4/9/07
Re: RLS, Akathisia + Dopamine D-2 receptors? hgi698 4/9/07
Re: RLS, Akathisia + Dopamine D-2 receptors? » hgi698 cache-monkey 4/9/07
sri, dopamine med_empowered 4/9/07
Re: RLS, Akathisia + Dopamine D-2 receptors? » cache-monkey Larry Hoover 4/12/07
Re: sri, dopamine » med_empowered cache-monkey 4/12/07
Re: RLS, Akathisia + Dopamine D-2 receptors? » Larry Hoover cache-monkey 4/12/07
Re: RLS, Akathisia + Dopamine D-2 receptors? » cache-monkey Larry Hoover 4/13/07
Re: RLS, Akathisia + Dopamine D-2 receptors? linkadge 4/14/07
Re: RLS, Akathisia + Dopamine D-2 receptors? » Larry Hoover cache-monkey 4/14/07

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