Posted by pseudoname on June 23, 2006, at 9:40:59
In reply to Bupe - a high potency partial agonist opioid » Declan, posted by ed_uk on June 21, 2006, at 14:23:45
Hi, Ed.
Thanks for that interesting abstract. I also thought it's interesting that it comes from India, which is one of the countries that has problems with black-market buprenorphine and smuggling. There's stuff in the news pretty regularly about it there.
I wonder what's going on in people for whom it's euphorogenic. Is it that their prioir opioid exposure has primed their brains? But it seems like that would make them *less* sensitive to it.
Is it that they're just naturally opioid sensitive people? But euphoria isn't reported as a common side-effect in Buprenex patients, many of whom would also presumably be naturally sensitive.
Euphoria wasn't reported by the opioid-naive patients in the tiny depression studies.
Nevertheless, I find the euphoria reports worrying unless they can be explained. Not for myself, but for bupe's chances for wider safe use and acceptance as a depression treatment.
> When injected, buprenorphine may resemble morphine and heroin in its effects.
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=9513799&query_hl=11&itool=pubmed_docsum
poster:pseudoname
thread:657263
URL: http://www.dr-bob.org/babble/20060623/msgs/660548.html