Posted by JaclinHyde on March 28, 2006, at 22:43:01
In reply to Re: Aiming for hypomania ? » scatterbrained, posted by linkadge on March 28, 2006, at 21:28:43
> Strictly speaking of AD's as a class of medications, the MAOI's actually can (and were discovered) based on their propensity to make well people slightly hypomanic, although I don't think its safe to promote them for this purpose.
>
> Perhaps I am just seeing into things, if so I apologise.
>
> LinkadgeHate to contradict you but the he MAOI's were developed as a potential cure for TB which at the time was running rampant. They found that these sick depressed patients ended up with a better outlook on life.
And I have 25+ years on this type of drug so I consider myself somewhat of an expert. And finally here is an article from the Harvard University Gazette on the patch.
"Selegiline is a so-called monamine oxidase inhibitor (MAOI), a class of drugs considered the most effective for fighting depression. "MAOIs are well-known for the completeness and robustness of their response," Bodkin comments.
Prozac-like drugs can cause headaches, anxiety, apathy, insomnia, nausea, and loss of sexual interest. Selegiline is free of such side effects. Prozac-like drugs relieve distress but usually do not produce a feeling of well-being. Selegiline and other MAOIs often leave patients feeling elated for the first time, a condition sometimes referred to as "remission with delight."
The first of these drugs was discovered accidentally in 1952 by David Bosworth, an orthopedic surgeon in New York City. While trying to find a drug to relieve the bone and joint pain of tuberculosis, he experimented with a new antibiotic known as marsilid. Coincidentally, marsilid is also an MAOI.
Along with relief from tubercular pain, Bosworth noted that his patients developed a state of elation and a feeling of vitality. The patient is left, noted Bosworth, with "a normally optimistic instead of a depressed attitude."
"This trial, like the first, is exciting not only because it is testing a new delivery system for a powerful treatment of the most common psychiatric disease in the world," Bodkin says, "but because it is resurrecting the first family of antidepressants ever introduced - ONE THAT HAS NEVER BEEN SURPASSED IN EFFICACY." (my caps)
The full article can be found here: http://www.news.harvard.edu/gazette/1998/12.10/depression.html
Peace,
JH
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