Posted by Jedi on November 27, 2005, at 5:53:29
In reply to Re: Linkadge, posted by Jakeman on November 27, 2005, at 0:08:35
> It's back to the much debated question. Do they work in the long-term? I had a good 2 year run on SSRI's. Then the sexual dysfunction crept in, along with unrelenting insomnia. During that good period I managed to get a Masters degree and had a decent social life. Now I'm having trouble finding anything that works.
>
> warm regards ~JakeHi Jake,
I believe the long term use of SSRIs and SNRIs caused an apathy syndrome in me. It is hard to separate this from my primary depression because I am atypical with a certain level of apathy and anhedonia when I am depressed. Anhedonia(the inability to experience pleasure) can cause serious problems with your sex life. There has been research showing the atypical antipsychotics providing some relief to this syndrome, as an augmentation to SSRIs.
Take care,
JediJ Psychiatr Pract. 2004 May;10(3):196-9.
SSRI-induced apathy syndrome: a clinical review.
Barnhart WJ, Makela EH, Latocha MJ.
Department of Behavioral Health and Psychiatry, North Colorado Medical Center, Greeley 80631, USA.The authors review the literature pertaining to selective serotonin reuptake inhibitor (SSRI)-induced apathy syndrome. A literature search of Medline and International Pharmaceutical Abstracts from 1970 to the present was performed for relevant articles. Twelve relevant case reports and one open-label treatment trial were identified. An amotivational, or apathy, syndrome has been reported in a number of patients receiving SSRI treatment over the last decade. This adverse effect has been noted to be dose-dependent and reversible, but is often unrecognized. This phenomenon has caused significant negative consequences for adults as well as social and academic difficulties in adolescents.
[Efficacy of atypical antipsychotics in depressive syndromes.]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15738862&query_hl=3Olanzapine in the treatment of apathy in previously depressed participants maintained with selective serotonin reuptake inhibitors: an open-label, flexible-dose study.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12019662&query_hl=3
poster:Jedi
thread:582599
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