Posted by djmmm on September 9, 2005, at 10:50:02
In reply to Re: Does smoking affect core depressive symptomolo » SLS, posted by Chairman_MAO on September 9, 2005, at 8:49:58
> Think about it: so long as the dosages used do not result in excessive MAO (or other enzyme) inhibition, why would there be a problem? Just as one can combine clomipramine with an SSRI if need be, or strattera with nortryptyline as someone did on this board, you can combine two MAO inhibiting drugs.
>
> Too much MAO inhibitor can cause serious problems depending upon the drug, such as thrombocytopenia with tranylcypromine. However, so long as conservative doses are used, I do not see why there would be a problem. I have taken tranylcypromine with Nardil before to see if its DA effect would help out the sexual dysfunction (it didn't) and had zero complications.
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> I imagine TCP + PLZ could be especially safe, as TCP is "semi-reversible" or whatever you want to call it and phenelzine is irreversible. It's not like the two are even both suicide substrates!
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> I really wish they'd develop the GABA-T inhibiting metabolite of phenelzine into a drug of its own for epilepsy and anxiety; it would probably do very well.
>Phenylethylidenehydrazine is similar to the drug Sabril (vigabatrin) a GABA-T inhibitor...also, Wasn't there some question as to whether phenelzine's ability to increase GABA was also do to some other mechanism? (via GABA(A)--alpha 3 beta 1 gamma 2 subunits-- receptors)
poster:djmmm
thread:552302
URL: http://www.dr-bob.org/babble/20050909/msgs/552697.html