Posted by Chairman_MAO on September 9, 2005, at 8:49:58
In reply to Re: Does smoking affect core depressive symptomolo » Chairman_MAO, posted by SLS on September 9, 2005, at 0:58:10
Think about it: so long as the dosages used do not result in excessive MAO (or other enzyme) inhibition, why would there be a problem? Just as one can combine clomipramine with an SSRI if need be, or strattera with nortryptyline as someone did on this board, you can combine two MAO inhibiting drugs.
Too much MAO inhibitor can cause serious problems depending upon the drug, such as thrombocytopenia with tranylcypromine. However, so long as conservative doses are used, I do not see why there would be a problem. I have taken tranylcypromine with Nardil before to see if its DA effect would help out the sexual dysfunction (it didn't) and had zero complications.
I imagine TCP + PLZ could be especially safe, as TCP is "semi-reversible" or whatever you want to call it and phenelzine is irreversible. It's not like the two are even both suicide substrates!
I really wish they'd develop the GABA-T inhibiting metabolite of phenelzine into a drug of its own for epilepsy and anxiety; it would probably do very well.
poster:Chairman_MAO
thread:552302
URL: http://www.dr-bob.org/babble/20050909/msgs/552672.html