Posted by Larry Hoover on April 11, 2005, at 15:49:58
In reply to Re: Flip???, posted by reefer on April 11, 2005, at 13:48:20
> This makes me think you have impaired enzyme function. The codeine isn't being converted to morphine in your body. Poor metabolizers with impaired enzyme function (Cytochrome P450 2D6) comprise approximately 7% of Caucasian, 2% of African American, and 1% of Asian populations.
>
> Actually i'm a poor metabolizer of CYP2D6 myself, and codeine does have an effect on me, BUT it doesn't kill pain(doesn't work as an analgetic). So while still binding to opioid receptors, codeine might not be very addictive when not converted to morphine in the body.I'm a poor metabolizer at 2D6, too, and it sure makes a big difference for me to know that. So many psych drugs depend on that enzyme....many of my medication failures can be traced directly to my liver.
Lar
poster:Larry Hoover
thread:479222
URL: http://www.dr-bob.org/babble/20050408/msgs/482899.html