Posted by KellyM on December 29, 2002, at 19:52:24
In reply to Re: High doses of Nardil? What is DX?, posted by djmmm on December 29, 2002, at 11:38:28
> The theory behind lowering your dose after a certain period of time is based on the amount of time it takes for your body to resynthesize MAO.
>
> Irreversible MAOIs form a permanent covalent bond with the MAO enzyme..full recovery from this only occurs when new MAO is synthesized. So, theoretically, after you have achieved significant and effective MAO inhibition, only a "maintenance" dose of a MAOI would be needed.
>
> The problem lies in that MAOIs seem to have immediate effects on neurons, like, in the case of Parnate a driect stimulation of catecholamine release, or, in Nardil's case, direct effecs on the GABA system...so, even though you can keep MAO activity low with a maintenance dose, and get an antidepressant response, If you don't take the MAOI regularly, or the same dose regularly, you lose the immediate effects.Thanks djmmm for the explanation. Not to be lazy, but if you happen to know any links or sites which might have more info I'd appreciate it. If not, no problem...you gave be a good start :)
poster:KellyM
thread:133478
URL: http://www.dr-bob.org/babble/20021223/msgs/133719.html