Posted by Jaynee on April 15, 2002, at 16:41:30
In reply to Magic anxiolytics, anyone? , posted by Thrud on April 14, 2002, at 7:23:12
I am on Celexa, but it wasn't helping enough with the anxiety. It helped somewhat, but I have added Passion Flower tincture to it and it really helps. I buy Vogel tincture drops. Give it a try, it can't hurt.
From PUBMED:
Abstract
Journal of Clinical Pharmacy & Therapeutics
Volume 26 Issue 5 Page 363 - October 2001
Passionflower in the treatment of generalized anxiety: a
pilot double-blind randomized controlled trial with
oxazepam
S. Akhondzadeh PhD12, H. R. Naghavi MD1, M. Vazirian MD1, A. Shayeganpour
PharmD2, H. Rashidi PharmD2&M. Khani MSc2
Objective: Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A
double-blind randomized trial compared the efficacy of Passiflora incarnata extract
with oxazepam in the treatment of generalized anxiety disorder.Methods: The study was performed on 36 out-patients diagnosed with GAD using
DSM IV criteria. Patients were allocated in a random fashion: 18 to the Passiflora
extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day
plus placebo drops for a 4-week trial.Results: Passiflora extract and oxazepam were effective in the treatment of
generalized anxiety disorder. No significant difference was observed between the
two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the
other hand, significantly more problems relating to impairment of job performance
were encountered with subjects on oxazepam.Conclusion: The results suggest that Passiflora extract is an effective drug for the
management of generalized anxiety disorder, and the low incidence of impairment
of job performance with Passiflora extract compared to oxazepam is an advantage.
A large-scale trial is justified.
another study:J Clin Pharm Ther 2001 Oct;26(5):369-73
Related Articles, Books, LinkOut
Passionflower in the treatment of opiates withdrawal: a double-blind
randomized controlled trial.Akhondzadeh S, Kashani L, Mobaseri M, Hosseini SH, Nikzad S, Khani M.
Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue,
Tehran 13334, Iran. s.akhond@neda.netOBJECTIVE: Clonidine-based therapies have been utilized as the main protocol for opiate
detoxification for several years. However, detoxification with clonidine has its limitations,
including lack of efficacy for mental symptoms. Accumulating evidence shows the efficacy of
Passiflora incarnata extract in the management of anxiety. In our continuing study of traditional
medicines, which have neurotropic effects, this plant had an anxiolytic effect, which may be used
as an adjuvant agent in the detoxification of opiates by clonidine. We present the results of a
double-blind randomized controlled trial of clonidine plus passiflora extract vs. clonidine plus
placebo in the outpatient detoxification of 65 opiates addicts. METHODS: A total of 65 opiates
addicts were assigned randomly to treatment with passiflora extract plus clonidine tablet or
clonidine tablet plus placebo drop during a 14-day double-blind clinical trial. All patients met the
DSM IV criteria for opioid dependence. The fixed daily dose was 60 drops of passiflora extract
and a maximum daily dose of 0.8 mg of clonidine administered in three divided doses. The
severity of the opiate withdrawal syndrome was measured on days 0, 1, 2, 3, 4, 7 and 14 using
the Short Opiate Withdrawal Scale (SOWS). CONCLUSION: Both protocols were equally
effective in treating the physical symptoms of withdrawal syndromes. However, the passiflora
plus clonidine group showed a significant superiority over clonidine alone in the management of
mental symptoms. These results suggested that passiflora extract may be an effective adjuvant
agent in the management of opiate withdrawal. However, a larger study to confirm our results is
warranted.Publication Types:
Clinical Trial
Randomized Controlled Trial
poster:Jaynee
thread:103028
URL: http://www.dr-bob.org/babble/20020408/msgs/103158.html