Posted by SLS on May 18, 2000, at 7:44:41
In reply to Re: SSRIs: - Different (Cam), posted by PeterJ on May 18, 2000, at 3:53:39
Hi guys.
I just wanted to jump in with a few observations.1. It seems that a great percentage of people fail to respond at all to one SSRI (and perhaps do worse), and go on to respond fantastically when switched to another. At least, that's what I see here. I would find it hard to justify abandoning SSRIs after failing to respond to the very first one tried. It would be nice if there were statistics providing correlations between the non-response to a particular SSRI and response to another. Anyway, if I were a doctor and treating a patient with a de novo trial of an antidepressant using an SSRI, I would try a second SSRI before opting to switch to a different "class" of drug. Of course, the specific symptom profile of a patient must be taken into consideration, knowing that there are some statistical correlations between profile and drug response.
2. I rarely see anyone attribute the clinical differences that may exist between antidepressants within the same class to pharmacokinetic differences. Do these drugs accumulate differentially in different brain structures?
- Scott
poster:SLS
thread:33808
URL: http://www.dr-bob.org/babble/20000517/msgs/33870.html