Posted by Cam W. on May 18, 2000, at 2:13:48
In reply to Re: SSRIs: - Different, posted by PeterJ on May 17, 2000, at 23:05:42
Peter - Clinically, predicting how an AD will work is still very much a crap shoot. You see many side effects that the companies report as minimal (eg mentrual irregularities, weird rashes) every now and then.I have found that you can be burned by in vitro receptor binding information. If it were entirely accurate, then Effexor would bs strictly an SSRI, with mild norepinephrine side effects (at least a 1000-fold difference in k-values). This is not the case, as many people experience significant norepinephrine efficacy with Effexor.
Clinically, for depression though, I believe that if one has no to minimal response on a first antidepressant (eg SSRI), then the next step should be to use another AD from a different class (eg SNRI, NRI, TCA), as experience dictates. Other SSRIs can be tried upon subsequent failures (a second SSRI should probably be tried for OCD and/or panic disorder if the first SSRI doesn't work).
Interesting thread here. Good luck with the Celexa - Cam
poster:Cam W.
thread:33808
URL: http://www.dr-bob.org/babble/20000517/msgs/33857.html