Posted by Brainbeard on February 10, 2010, at 16:18:18 [reposted on February 21, 2010, at 13:24:08 | original URL]
In reply to Fluoxetine(prozac) is a 5-HT2A antagonist., posted by conundrum on February 10, 2010, at 12:24:34
> I had thought it was only a 5 HT2C antagonist but it also blocks the 5-HT2A receptor. This causes and increase in norepinephrine and dopamine. Other SSRIs don't do this.
It should be noted, however, that the very mechanism of serotonin reuptake inhibition acts as an indiscriminate 5HT agonist, which means that Prozac's SRI counteracts its 5HT2A and -C antagonism. I guess some will still hold up, but, for instance, the typical deep sleep-inducing properties of 5HT2A-antagonism are clearly swept away by Prozac's other actions.
poster:Brainbeard
thread:937575
URL: http://www.dr-bob.org/babble/neuro/20091104/msgs/937576.html