Posted by JLx on November 14, 2004, at 18:42:34
In reply to Re: SAMe augmentation for resistant MDD, posted by JLx on November 14, 2004, at 17:59:24
> > > > You can substitute trimethylglycine plus B12 for the SAMe. They're precursors and some (including Larry) consider this to be a more efficient way to go as well.
> > >
> > > Do you know what the monthly cost of this would be?
> > >
> > >
> > > - Scott
> >
> >
> > It's quite a bit cheaper than SAM-e. I need to find Larry's old posts to see about the dosage range of TMG + B12 he recommends so I could give you some accurate figures. You might need to add in folate to balance the B12 as well. SAM-e works for some people in varrying dosages - anywhere from 200-1600 mg. a day - so your cost would vary considerably based on dosage required.
> >
> > I'll do a little searching for those old posts later and get back to you on this (assuming that Larry or someone else doesn't get to it first).
> >
> >
> > K
> >
>
> Here's one thread from a year ago: http://www.dr-bob.org/babble/alter/20031104/msgs/278139.html There's a lot of info in Larry's posts there. DSCH also makes an important note, I think, that it was magnesium that "turned on" TMG for him.
>
> TMG is availble through Beyond a Century in bulk form, so inexpensive that way. It's tolerable tasting dissolved in water.
>
> JLI was reading over that old thread...so glad to have this documentation sometimes! I see I was taking about 800 mg of TMG 3 times a day. I didn't realize it was so much and though I have been taking it again lately, not that much. I was feeling loads better in those days too.
I have noticed that taking the TMG feels different since I've been taking MSM, but again maybe I'm not taking enough. What exactly is the relation to TMG and MSM, other than that they are methyl donors? I usually take 1-2,000 mg of MSM, though I've been slacking off lately. Hmm...maybe this is why I feel more crappy.
This board is so helpful. :)
"Research has found that TMG is converted into SAM in the body. TMG is less expensive than SAM.
Dosage: 3,000 milligrams a day, followed by a maintenance dose of 1,000 milligrams a day for up to three weeks." http://www.holistic-online.com/Remedies/Depression/dep_nutrition2.htm#TMGI'm reading "Optimum Nutrition for the Mind" and Patrick Holford recommends TMG 600-2000 mg daily on an empty stomach or with fruit.
JL
poster:JLx
thread:415835
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/415958.html