Posted by jboud24 on October 19, 2004, at 15:51:49
In reply to Re: Selegiline Phenylalanine » sfy, posted by Larry Hoover on October 19, 2004, at 14:49:05
Mirtazepine is the strongest anti-histamine on the world market. Its Ki binding value for the histamine H1 receptor is .12. Doxepin comes in second at .20, and remember that the lower the Ki value, the lower the drug plasma level needed for affecting a particular receptor. This means that lower = more potent.
In addition, Remeron and most other tricyclic ADs are sedative due to their strong binding at the serotonin 2a receptor. Remeron also affects the serotonin 2c recptor with equal potency relative to the 2a receptor which is another mechanism for sedation. Trazodone, for instance, provides sedation almost intirely through antagonism of the 2a receptor, and the same is true of Serzone.
I hope this helps.
Justin
poster:jboud24
thread:377600
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/404808.html