Posted by karaS on October 19, 2004, at 14:14:53
In reply to Re: Supplements for brain fog? » karaS, posted by raybakes on October 19, 2004, at 9:51:41
> Hi Kara, found these abstracts today...
>
> Grima, G., B. Benz, et al. (2003). "Dopamine-induced oxidative stress in neurons with glutathione deficit: implication for schizophrenia." Schizophr Res 62(3): 213-24.
>
> Glutathione (GSH) is the main non-protein antioxidant and plays a critical role in protecting cells from damage by reactive oxygen species (ROS) generated by dopamine (DA) metabolism. We reported a decrease of GSH levels ([GSH]) in CSF and in prefrontal cortex in vivo in schizophrenics [Eur. J. Neurosci. 12 (2000) 3721]. A GSH deficit may lead to membrane peroxidation and microlesions around dopaminergic terminals, resulting in loss of connectivity. To test this hypothesis, we studied the effect of DA in cultured cortical neurons with low [GSH]. DA alone decreased [GSH] by 40%. This effect appears to result from direct conjugation of DA semiquinone/quinone with GSH. Ethacrynic acid (EA) decreased [GSH] in a concentration-dependent manner. When added to EA, DA further lowers [GSH]. As this additional decrease is blocked by superoxide dismutase (SOD) or D(1)/D(2) receptor antagonists, it likely involves the generation of superoxide via activation of DA receptors. It also reduces the mitochondrial membrane potential. Most interestingly, a significant decrease in number of neuronal processes (spines analogous) was induced by 24-h application of DA only in low [GSH]. These data, compatible with our hypothesis, is consistent with the dendritic spines reduction reported in schizophrenia and could be related to abnormalities in synaptic connectivity.
>
> And this one..
>
> http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.neuro.27.070203.144206;jsessionid=j96WSOG9YwX9
>
> also bought a good book on the thyroid today called "the great thyroid scandal and how to survive it"
>
> Ray
Thanks Ray.
I was taking 1200 mg. of NAC for a while but didn't notice any relief. Wouldn't that have provided enough glutathione had that been my problem or is that more the kind of thing where it would take a long time to see any kind of difference? Also, I read another post here a little while back about the perils of taking NAC when you have mercury amalgams (which I have) so I'm a bit worried now about taking it again.
In terms of the second abstract about the G protein-coupled receptor kinases (GRKs), I can't help but think that by the time they have something on the market for that I'll be much too old to care. I really do appreciate your sending me the abstract though. I guess I'm just feeling sorry for myself now. Ok, time for some CBT. Talk to you later.
Kara
poster:karaS
thread:359642
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/404757.html