Posted by tealady on October 16, 2004, at 4:59:25
In reply to Re: Supplements for brain fog?, posted by karaS on October 16, 2004, at 0:50:05
> > The other article talked about tryptophan excess altering the sensitivity of the dopamine receptors - so maybe something that antagonizes dopamine, may make it's receptors overly sensitive, as a compensation? what do you think?
>
> > "The greater prolactin response to l-tryptophan infusion in depressed subjects may be the result of an increase in dopamine receptor sensitivity, secondary to reduced dopamine levels."
> >II'm probably completely off course here, that the problem may be caused by competition for the same enzyme cofactors ...
Dopamine is produced from tyrosine by the action of tyrosine hydroxylase (TH), which uses tetrahydrobiopterin (BH4) as a cofactor. BH4 is also a cofactor for tryptophan and serotonin synthesis, and also for the enzyme nitrous oxide synthetase
or possibly its P5P B6 which I THINK is needed by somehow by tyrosine hydroxylase ?(not sure here) , and low adrenal function meaning it can take up to 21 days(heard that from a doc) to resynthesize enough tyrosine hydroxylase..not sure of this but I think it fits in somewhere with the competiton theory too.
The competiton means making too much of one(say serotonin) will deplete the ability to make the other (say dopamine)..and depletion will eventually cause oversensitivity of the related receptorsI guess.hmm guess I must be low on serotonin looking at this
Jan
http://www.genome.jp/dbget-bin/show_pathway?map00350+1.14.16.2
http://www.genome.jp/dbget-bin/show_pathway?map00380+1.14.16.4
poster:tealady
thread:359642
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/403751.html