Posted by JLx on October 4, 2004, at 10:54:26
In reply to Re: Inflammation question for raybakes » JLx, posted by raybakes on October 3, 2004, at 8:56:02
> I think you're right, I think your virus and immune reaction are behind you going downhill.
Hmm...I wish I'd known that, I might have been a bit less panicky and self-blaming.
<(lactoferrin works really well at inhibiting the early stages of viral replication).
I never heard of it before, but was just reading about it. What kind do you take?
>This abstract talks about the rise cortisol caused by an inflammatory response.
I'm just amazed by how much depression seems to coincide with all these stress responses. What do you think is best to reduce cortisol/inflammation?
> The cox enzyme that ibuprofen inhibits is downstream from the release of cytokines that trigger prostaglandin production, so ibuprofen will only deal with some of the inflammatory effects, but not deal with the triggers - and it's the triggers (cytokines) that have a direct effect on the nervous and endocrine system.
Ah. I knew it had to be something like that.
> Fish oils are also cox inhibitors, and also inhibitors of PLA2 (phospholipase A2) the enzyme that breaks down the phospholipids in the cell membrane, that results in an inflammatory cascade. PLA2 is more upstream than COX, so it's inhibition has more effect on depression.
What do you think is a good amount and in what ratio of EPA or DHA? I've read conflicting advice here and in the various links people have posted.
> I've been reading about the cytokines for several years, it takes quite a while to get a handle on them, but it's worth sticking with it,
If you say so. <g>
> So what can inhibit the cytokines?!Glutathione, inhibits the enzymes that release them, lactoferrin, DPP IV (from kirkman labs) helps break them down, niacinamide inhibits them (maybe because glutathione needs NADPH) and also helps inhibit the trytophan degrading IDO enzyme. I'm sure there's others, especially other antioxidants, but glutathione is involved in recyling antioxidants that have mopped up a free radical, so so much of it is a team effort!
Well, at least I like the foods that have the most glutathione. Usually when something is supposed to be "good for you" I have to groan as it's on my hate list. ;)
> Hope that's not too much info!
Thanks for your help. You seem like a sweet guy. Now that I've buttered you up.... :)
Bottom line, what's the best thing to prevent inflammation as pertaining to depression? My funds are limited, and I already take niacinamide and fish oil.
JL
poster:JLx
thread:398076
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/398782.html