Posted by SLS on February 16, 2023, at 18:19:24
In reply to An update, posted by tensor on February 16, 2023, at 8:47:54
Hi, Tensor.
> Had a call with my doc today so here's an update. Maybe it can be useful to someone in the future.
> There is a consensus on my psychiatric hospital that pregabalin is not prescribed because of too many bad experiences. We started talking about alternatives like anti-psychotics, I suggested Latuda to take regularly but we agreed it's better to take an anti-psychotic as needed, since the severity of my anxiety increases in certain situations/circumstances. She said Latuda is too week, and she suggested Chlorprothixene which is an FGA. I already picked it up from the pharmacy and took a low dose of 15mg 30 minutes ago. I can already feel a nice calming effect but it's too early to tell how it will work for me, but it feels promising.
> If you are in a similar situation, consider a medication like this.
>
> /tensorNardil (phenelzine), an irreversible monoamine oxidase inhibitor (MAOI). It is perhaps the best treatment available for social anxiety / phobia. It is also effective to various degrees to treat GAD, Panic Disorder, and OCD.
Would you describe your anxiety as being the result of social phobia or social anxiety? If not, under what circumstances do you experience anxiety?
Some people use propranolol as a PRN to be taken before being exposed to an anxiety-provoking situation. It is sometimes used by people who engage in public speaking.
Which benzodiazepines have you tried? Your doctor is absolutely right with the way he portrays Lyrica (pregabalin). My experience with it was pretty bad. After my first few doses, it made me feel less depressed and somewhat calmer. However, after a few more days, I felt dysphoric and smothered by severe brain fog. I became numb to the world around me. After discontinuing Lyrica, it took three weeks for these mental aberrations to dissipate. The drug is unpredictable. I am going to suggest another unpredictable drug - Gabitril (tiagabine). Gabitril is a GABA reuptake inhibitor - the only drug of its type available. GABA is the most ubiquitous inhibitory neurotransmitter found in the brain, and offsets overactivity - anxiety. Some people report a positive outcome with Gabitril. However, it can also produce what is likely to be a disinhibition phenomenon that manifests as anger, irritability, agitation, hostility, and rage. Given your dwindling alternatives, I think Gabitril is worth a try. If you react badly to it, you will know quickly.
By the way, the GABA receptor is the site where benzodiazepines act to amplify GABA inhibitory (anti-anxiety) neurotransmission. The site where bendzodiazepines bind to is actually offset from the GABA binding site of the GABA receptor complex. It functions as a co-receptor to increase the sensitivity of the GABA receptor complex to the GABA neurotransmitter molecule.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1121774
URL: http://www.dr-bob.org/babble/20230117/msgs/1121804.html