Posted by SLS on January 25, 2023, at 7:09:30
In reply to Re: Lithium biochemistry (low level mechanisms) » SLS, posted by undopaminergic on January 25, 2023, at 4:47:57
> > Hi, UD.
>
> Hi SLS.
>
> > > Note: no clinically applicable information.
> >
> > My concern with the posting behavior on PB isn't that all posts should be clinically applicable. My concern is that there aren't nearly enough. Pure neuroscience research is extraordinarily valuable, but more so for those who will come after us. Can someone use what they learn from research papers to design a treatment? Of, course they can. Unfortunately, this is uncommon.> I've always largely (perhaps excessively) allowed the theory to guide me, and that includes research articles. For example, I was interested in vortioxetine (which I'm on right now) because I had read it acts on serotonin 5-HT3 receptors, which was interesting to me because I had never tried anything else with an effect on those receptors.
Are you still taking vortioxetine?I think scientists had been focusing on the ability of vortioxetine to antagonize 5-HT7 receptors. However, the drug does so many different things, that it is sort of like throwing as much crap at the the serotoninergic wall (serotonergic receptors and SERT), that some of it is bound to stick.
> > Not only does a psychiatrist learn from his own track record, but he also learns from the track records of his buddies.> Yes.
> > Psychiatry is guess-work.
> Yes.
>
> -undopaminergicI hope that your incorporation of pure research to your treatment strategies yields a robust response. The combining of MAOI with TCA was also based to a great degree on the basic research performed in the late 1970s and 1980s.
Whatever works.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1121631
URL: http://www.dr-bob.org/babble/20230117/msgs/1121639.html