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Guanfacine + NAC for PTSD, TBI, ADHD, long Covid

Posted by Hugh on January 6, 2023, at 8:34:11

Twelve patients with "brain fog" including difficulties in executive functions were treated with guanfacine (1mg, PO [by mouth] bedtime for the first month, increased to 2mg after 1 month, if well-tolerated) and 600 mg NAC daily.

Guanfacine+NAC improved cognitive abilities in eight of the twelve patients; four patients discontinued therapy, two for unspecified reasons and two due to hypotension and/or dizziness, common side effects of guanfacine.

Those who stayed on guanfacine+NAC reported improved working memory, concentration, and executive functions, including a resumption of normal workloads. One patient briefly stopped taking guanfacine due to a hypotensive episode and reported a return of cognitive deficits that abated with resumed guanfacine treatment.

https://www.sciencedirect.com/science/article/pii/S2667257X22001000?via%3Dihub

https://www.yalemedicine.org/news/long-covid-brain-fog-treatment


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poster:Hugh thread:1121495
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