Posted by SLS on December 31, 2022, at 17:28:38
In reply to Re: Tentative remission on ketamine, posted by undopaminergic on December 31, 2022, at 14:03:45
Hi, UD.
> In my view, NMDA-glutamatergic receptor antagonists, like ketamine or memantine, enhance the *functional* dopaminergic tone, without necessarily elevating dopamine concentrations at all.
What is "dopaminergic tone"?
How does blocking NMDA receptors result in increased dopaminergic tone?
Thanks.
I am clueless as to what NMDA receptors are all about, other than their endogenous ligand is glutamate.
- Scott
this signature | Show by default | Change to hide (next time)Some see things as they are and ask why.
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poster:SLS
thread:1121402
URL: http://www.dr-bob.org/babble/20220917/msgs/1121435.html