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Re: MAOI vs SSRI » SLS

Posted by undopaminergic on October 28, 2022, at 11:41:12

In reply to Re: MAOI vs SSRI » undopaminergic, posted by SLS on October 28, 2022, at 8:54:14

> >
> > > What if you took an anti-manic along with the memantine?
> > >
> >
> > That might be worth trying.
> >
> > -undopaminergic
>
>
> If Zyprexa (olanzapine) has had any beneficial effect for depression when added,
>

I'm not entirely sure about this, but once olanzapine seemed to help my motivation briefly (as in one dose, possibly two). I've read that serotonin 5-HT2A antagonists can increase dopamine release in the prefrontal cortex, but I also seem to recall that this effect was not sustained with chronic dosing.

> regardless of the amount of time that it provided benefit, this might be an indicator that adding the right atypical antipsychotic might act as a synergist to memantine in treating your depression and also prevent mania. Since weight-gain is often a side effect of Zyprexa, finding another AP might solve that problem. Saphris (asenapine) and Latuda (lurasidone) come to mind. I don't know enough about Fanapt (iloperidone), but I would search the Internet for information.
>

Well, I'm on clozapine, trimipramine, and sulpiride, so I don't need more antipsychotics. Alas, I'm not in a position to take memantine at this time.

> The other anti-manic strategy is to use anticonvulsants. Trileptal (oxcarbazepine), Depakote (valproate), topiramate (Topamax) are worth looking into. They sometimes demonstrate antidepressant effects when used as an adjunct to antidepressants.
>

That is interesting. I take 200 mg/day of lamotrigine, but I'm inclined to think it has no effect.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20220917/msgs/1120923.html