Posted by SLS on April 9, 2022, at 20:16:54
In reply to Re: Combining Prozac and Paxil.... » SLS, posted by Jay2112 on April 8, 2022, at 22:35:25
Hi, Jay.
> I found that my supposition regarding the possibility of there being subtypes of the serotonin transporter (SERT) has a factual basis.
>
> "The human serotonin transporter gene (5-HTT) demonstrates two polymorphisms with possible functional impact: a 44-bp insertion/deletion polymorphism of the promoter region and a 17-bp variable number of tandem repeat polymorphism (VNTR) in intron 2 (STin2)."
>
> https://www.nature.com/articles/4000821
>
> I propose that two different serotonin transporters might need two different drugs (ligands) to block both of them robustly. Of course, one drug might be able to attach to both SERT subtypes equally.
>
> For you, Jay, the question is whether or not venlafaxine and citalopram are each selective for a different serotonin transporter subtype. If so, that would explain your superior response to a combination of both drugs.> Very interesting Scott! There is so, so much that we have yet to discover. To this day, even after almost 30 years as a psychonaught (lol), I am still 'fine tuning' my drug regiment. I retry old drugs that partially worked, in combo's with new drugs that partially work. I find that doing 'spurts' of drugs for 2-3 days, stopping for a few, then continuing (doing the start-stop always) seems to prevent the 'getting used of..' phenomenon.
As you have commented many times in the past, our patterns of reactions to drugs are very similar.
I managed to develop a destructive habit of changing drug dosages too quickly. With both Nardil and Parnate, I would get a short, but significant improvement when increasing OR decreasing the dosages. I was too easily fooled. So many drugs have "tickled" my brain into having a brief improvement that usually lasted for no more than 3 days.
> But, I have to admit, it is getting tiring as I get older. <sigh> :(
Truthfully, I don't know how any of us on this site have made it this far. Now that I am feeling better, I have a much greater appreciation for horrendous existence that we have all endured. It takes a heroic effort to wake up each morning and to look forward only to escaping into sleep again that night.
Your words leave me with the impression that, although you might be tired at the moment, you still have plenty of positive energy.
I wish I could tell you with certainty that you will achieve remission tomorrow. I can't, obviously. However, who among us can claim to be certain that you won't? Uncertainty is what has kept you alive this long. I don't see that changing with you any time soon.
The only thing I can do for you right now is pray.
Okay. Done.
I pray it helps.
:-)
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1119194
URL: http://www.dr-bob.org/babble/20220128/msgs/1119307.html