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Re: Psychedelics - Mechanisms

Posted by Jay2112 on March 19, 2022, at 10:48:13

In reply to Re: Psychedelics - Mechanisms, posted by linkadge on March 18, 2022, at 19:40:01

> Interesting, I wonder if MCPP, a metabolite of trazodone which is also a 5-ht2a/c agonist might participate in the therapeutic properties of the drug.
>
> Many psychiatric drugs are 5-ht2a/c antagonists, so it's hard to reconcile their effects when 5-ht2a agonists are apparently effective for a similar set of disorders.
>
> I read an article about how LSD did *not* share the same lasting antidepressant effects that psilocybin and that researchers had developed analogues of psilocybin which had antidepressant but not hallucinogenic effects.
>
> Linkadge
>

Yeah, I have wondered the same about 5ht2 antagonists/agonists. I responded greatly to nefadozone, an antagonist, but not so much trazodone. So, I wonder about the agonism property of psilocybin.

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:Jay2112 thread:1119005
URL: http://www.dr-bob.org/babble/20220128/msgs/1119052.html