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Re: Vortioxetine (Brintellix-Trintellix) SLS

Posted by undopaminergic on November 17, 2021, at 14:17:16

In reply to Re: Vortioxetine (Brintellix-Trintellix) undopaminergic, posted by SLS on November 17, 2021, at 9:55:34

> Hi, UD.


> Vortioxetine didn't help me at all. It didn't make the depression itself worse, but it left me in a profound state of brain-fog.

Interestingly, I've seen several reports from people for whom it *treated* brain-fog. I have had chronic brain fog for years and still do.

> Immediately after I switched from vortioxetine to Effexor, my depression became dramatically worse, and I decided to commit suicide. This is as close as I ever came to doing it. I was at a friend's house, and, of course, I wasn't going to leave her with my dead body to deal with. I had NEVER had a negative reaction to Effexor during the five or more times that I had taken it. It sometimes helped. My best guess is that pre-treatment with vortioxetine set the brain up for this severe reaction to Effexor. If vortioxetine were a wonder-drug, I think we would all have known it by now.

It's obviously not a wonder drug for everyone; some say it's the worst drug they've been on. For others it does work wonders.

Nausea is a very common adverse effect of vortioxetine, so we can be pretty sure that many people quit it prematurely; for some of them it would have helped.

> My advice to you is that you try it vortioxetine if you have run out of options that have a low probability of working. You never know.

You know that you never know how a particular drug is going to affect a particular individual. The other options at this time are clomipramine, asenapine, or even venlafaxine. However, the wheels are already in motion as far as vortioxetine is concerned. I'm lucky if I get to try any of them!





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