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Ultra-low-dose phenytoin may enhance GABA

Posted by Hugh on October 9, 2019, at 9:13:09

Extremely low doses of phenytoin could help some people with depression and anxiety -- and many other ailments. Phenytoin (Dilantin) is an anticonvulsant that has been used to treat epilepsy for over 80 years.

Philip Bird, an Australian physician, thinks that low doses of phenytoin may enhance GABA neurotransmission, thereby correcting the imbalance between the GABAergic and glutaminergic systems.

In this patent application, Bird discusses the use of ultra-low-dose phenytoin to treat dementia, reading disorder, ADHD, acquired brain injury, visual fatigue, autism, PTSD, schizophrenia, bipolar disorder, chronic pain, tinnitus.

If you scroll to the bottom, Bird lists numerous examples (case reports). For most of them, the ideal dose of phenytoin appears to be 2-3 mg. Some patients responded better to a dose of 1 mg. One patient responded best to 0.5 mg. One patient responded best to 0.1 mg.




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