Posted by SLS on May 9, 2016, at 8:02:32
In reply to Venlafaxin mode of action?, posted by Lamdage22 on May 9, 2016, at 7:18:41
> So Venlafaxine is partially effective for me. Is this to be explained solely by Serotonin/Noradrenalin reuptake inhibition or does Venlafaxin have any other actions?
While in development, it was claimed that venlafaxine (Effexor) produced significant dopamine reuptake inhibition. It was even first touted as being the non-MAOI MAOI. If it does do this at all, it would occur at higher dosages.
Venlafaxine may have additional pharmacological properties that I am unaware of - or even that researchers are unaware of. Sometimes you have to ignore the theory and pay more attention to the clinical properties. When first approved, venlafaxine was not to be prescribed at dosages above 225 mg/day. However, clinical practice indicated that this was too low, and the maximum recommended dosage was changed to 375 mg/day. Perhaps it is necessary to go higher than 225 mg/day in order for venlafaxine to exert a significant amount of dopamine reuptake inhibition.
To answer your question, I don't know what is the mode of action of venlafaxine to treat depression. I'm not sure that scientists are ready to declare with certainty an understanding of how venlafaxine works.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1088804
URL: http://www.dr-bob.org/babble/20160501/msgs/1088805.html