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contradictory studies on propranolol + fear ext?

Posted by Franz on October 12, 2014, at 13:19:28

In reply to Re: New study Re: Alprazolam + atenolol, posted by P2thaJ on October 2, 2014, at 16:43:39

Role of beta-adrenergic receptors in the ventromedial prefrontal cortex during contextual fear extinction in rats.
http://www.ncbi.nlm.nih.gov/pubmed/20667477

Our results reinforce the role of the vmPFC in fear extinction mechanisms, suggesting that vmPFC-beta-1-adrenergic receptor activation underlies part of the facilitation of the fear extinction processes.

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Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695810/

Propranolol reduced the expression of conditioned fear, without interfering with extinction learning.

Isn't there a contradiction? Does propranolol help or interfere with fear extinction? Any specialist here can clarify please? Thanks!

 

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URL: http://www.dr-bob.org/babble/20140914/msgs/1072144.html