Posted by Louisiana Sportsman on April 14, 2014, at 20:18:34
In reply to Re: replace Abilify with perphenazine? » Christ_empowered, posted by Louisiana Sportsman on April 14, 2014, at 19:59:50
http://www.schizophrenia.com/sznews/archives/002424.html#
"Perphenazine (the older medication) equally as effective as the other three newer medications (risperidone, quetiapine, and ziprasidone) and was as well tolerated as the newer drugs. The three newer medications performed similarly to one another.
Contrary to expectations, movement side effects (rigidity, stiff movements, tremor, and muscle restlessness) primarily associated with the older medications were not seen more frequently with perphenazine than with the newer drugs. The advantages of olanzapine in symptom reduction and duration of treatment over perphenazine were modest and must be weighed against the increased side effects of olanzapine.
Thus, taken as a whole, the newer medications have no substantial advantage over the older medication used in this study. An important issue still to be considered is individual differences in patient response to these drugs."
The dosage of perphenazine used in the CATIE study http://www.nejm.org/doi/full/10.1056/NEJMoa051688#t=articleResults was 20.8mg.
The perphenazine/amitriptyline combo comes in:
- Tablets 2 mg perphenazine/10 mg amitriptyline
- Tablets 2 mg perphenazine/25 mg amitriptyline
- Tablets 4 mg perphenazine/10 mg amitriptyline
- Tablets 4 mg perphenazine/25 mg amitriptyline
- Tablets 4 mg perphenazine/50 mg amitriptylineMaintenance dose for amitriptyline is 25 to 150 mg per day in single or 3 to 4 divided doses.
You could try #150 4 mg perphenazine/25 mg amitriptyline?
poster:Louisiana Sportsman
thread:1063976
URL: http://www.dr-bob.org/babble/20140328/msgs/1064221.html