Posted by tom2228 on March 17, 2014, at 22:17:15
In reply to Re: TCAs calming vs. sedating/ nortrip vs. Saphris SLS » tom2228, posted by phidippus on March 17, 2014, at 21:56:58
> > I was thinking of desipramine because of its least side effects in general
>
> It has the same anticholergenic side effects the rest of the TCAs have.
>
but the least anticholinergic among the TCAs? -- according to the table on the wiki article for tricyclic AD , despiramine has Kd of 232.6 nm at mAChR (average?) -- at least compared less to nortrip (94 nm) and much less than protrip (25 nm)?> > My depression is severe and I'm nervous that if she won't go for the combo that the TCA alone won't be enough
>
> Desipramine alone will not be anywhere near as effective as Marplan. Your best bet would be to add the drug.What would you recommend if she says no to the MAOI + TCA combo?
>
> , so I was wondering about nortriptyline.
>
> It is a straight up NRI (norepenephrine reuptake inhibitor) and unlike Desipramine has little or no effect on serotonin.Are you sure or am I reading this wrong?
according to the table, despiramine has (Kd) 179nm for SERT and 2.27 for NET, while for nortrip the numbers are 16.5 for SERT and 1.65 for NET, and for protrip 19.6 nm (SERT) and 1.41 nm (NET)
>
> > That being said, is the nortripyline sedation more calming, or is it more of the heavy, tiring, sleepy, mind-blocking type?
>
> It was more calming for me.
>
> Is nortrip, desipramine, or protrip good for anergic bipolar depression?
>
> yes
>
> >am thinking of asking to decrease or switch to Invega as it's said to be the least sedating AAP.
>
> I had trouble sleeping on Invega. It is very energizing in some ways.Was Invega at all calming for you? How about for agitation?
>
> >how does nortrip's compare to Saprhis in this respect.
>
> I would say Saphris is a lot more sedating than Nortryptaline
>
> My recommendation is to request to add Nortryptaline to your Marplan and switch to Invega, but be aware you may lose some antidepressant benefits when you go off the Abilify. Maybe Latuda would be a better switch.
>Tried Latuda. It's funny, most meds I try have benefits I like and aspects that make my issues worse. Like Abilify -- brighter on my mood, helps with the obsessive nature of my thoughts/ tendency to ruminate, and can be calming -- but is activating in an annoying way, yet makes me very sleepy, and sucks up my interest in life
> Eric
Thanks for your reply Eric.
poster:tom2228
thread:1062693
URL: http://www.dr-bob.org/babble/20140307/msgs/1062703.html